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This process is mediated by enzymes such as NADP(H) oxidases and xanthine oxidase (Figure 1, reactions a and b) or nonenzymatically by redox-reactive compounds, such as the semi-ubiquinone compound of the mitochondrial electron transport chain (Figure 1, reaction c)

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Williams RL, Courtneidge SA, Wagner EF (1998) Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene