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Treatment updates and alternatives While the mechanism of toxicity in paracetamol overdose is thought to be due to glutathione depletion and subsequent buildup of harmful metabolites as previously mentioned, studies on the repletion of glutathione as a therapy option are few and in early stages but yielded positive results

Glutathione Implication in Protein Deglutathionylation S -glutathionylation of proteins is spontaneously reversible in reducing conditions, but the process can be accelerated by enzymes

Giving GSH directly as a supplement by mouth does not consistently help raise glutathione levels because it is negatively affected by digestion

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