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1 - 13 Furthermore, this has some physiologic importance (i.e., controlled NO-generation, providing that in the stomach BPC 157 induced NO-released opposed L-arginine-induced NO-release, and that BPC 157 induced NO-released is completely resistant to L-NAME application unlike L-arginine)

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In this review, we present the growing circumstantial evidence suggesting that IRPs play critical roles in the adaptive response to ferroptosis and ferroptotic cell death and describe how this knowledge can be leveraged to target neoplastic iron dysregulation more effectively