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intestinalis including gene products (highlighted in gray) contributing to the biosynthesis of glutathione [GCLC, GCLM, GSS, GGT1, xCT (SLC7A11)], its use as a redox buffer [GLRX, GPX1, GSR], and as a conjugate in phase II detoxification [GSTA1, GSTM1, GSTP1, MRP2 (ABCC2)], as well as known transcriptional regulators [NRF2 (NFE2l2), KEAP1, MAFF, BACH1, LXRA (NR1H3), FXR (NR1H4), and RXRA]

Consequently, FA levels inside cells need to be strictly controlled by specific mechanisms that metabolize it into less reactive molecules, such as formate

2.2 Oxidative stress-related biomarkers 2.2.1 Protein deglycase-1 (DJ-1) The PARK7 gene encodes a multifunctional protein known as DJ-1, whose structure and function can be changed by mutations in PARK7, resulting in an autosomal recessive illness that raises the risk of PD