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Further investigation is needed to explore how Epitalons impact on global methylation patterns could influence gene expression related to oxidative stress, EMT, and fibrosis in DR

Elective surgery has also long been used as a paradigm of the stress response in humans (188-190): the magnitude of cortisol rise correlates positively with the severity of surgery (191)

Preservation of Mitochondrial DNA (mtDNA):mtDNA lacks protective histones and is located near the ROS-generating inner mitochondrial membrane, making it highly susceptible to oxidative damage