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Discuss the importance of having access to an opioid overdose reversal agent, especially if the patient has risk factors for overdose (e.g., concomitant use of CNS depressants, a history of opioid use disorder, or prior opioid overdose) or if there are household members (including children) or other close contacts at risk for accidental ingestion or opioid overdose

Conversion to the corresponding -imino and -keto acids, and to -ketobutyrate and methane sulfonamide

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INTRODUCTION Vaccination remains one of the most effective interventions in medical history, yet the development of potent immunogens against highly mutable pathogens, such as HIV and influenza, continues to defy conventional empirical approaches