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The NAD stated that while it recognized that in vitro studies can provide some background evidence about a substance, suggesting further clinical research, in vitro studies are of limited value in predicting the effect of a substance when consumed by humans and in most cases such studies cannot by themselves support health claim[s]. With respect to pilot clinical studies, the NAD stated, Generally speaking, a pilot study is a small-scale preliminary study conducted to evaluate feasibility, time, cost, adverse events, and effect size (statistical variability) for further research. The NAD expressed concern about the reliability of extrapolating information from preliminary findings to support performance claims

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Different effects of a perioperative single dose of dexamethasone on wound healing in mice with or without sepsis