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Targeted Deprivation Cancer cells adaptability in acquiring nutrients even when they are scarce makes any simple approach to cutting off cancers glutamine supply likely to fail

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Patients presenting with deep-seated metabolic resistance, hypothyroidism, menopausal hormonal shifts, or chronic inflammatory states often struggle to lose weight even when adhering to strict caloric deficits

Additionally, PDAC cells-derived galectin-3 has been reported to activate PSC and enhance ECM production through activation of the NF-B signaling pathway, contributing to the crosstalk between the two cells and remodeling of the desmoplastic microenvironment 20