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Agents targeting the gut microbiome and the gutliver axis Alcohol consumption disrupts the intestinal mucosal barrier, leading to dysbiosis and increased gut permeability

Supporting this, a Y353R mutant increased the specificity of SpNOX for NADPH fourfold (Supplementary Fig

Exceptional safety margin No dependence or tolerance naturally occurring endogenous peptide Tolerability in clinical trials No tolerance develops with repeated doses No withdrawal symptoms upon stopping Peptide naturally present in the human body Research considerations Researcher's notes Outstanding safety profile for a bioactive peptide No serious adverse events were reported in the published studies

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