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10.1371/journal.pbio.2006203 PLoS Biol

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However, it is worth noting that, although metformin is generally well-tolerated in the treatment of PCOS and no serious adverse events or hepatic or renal dysfunction were observed during the clinical period, the most commonly reported side effects are short-term gastrointestinal disturbancesincluding nausea, bloating, and diarrheawith roughly one quarter of adult participants experiencing these symptoms yet continuing the medication, and a small number of adolescents discontinuing treatment after gastrointestinal reactions persisted for more than two weeks