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I dont have PA but its very likely that I have a genetic issue with processing vitamin B12 and breaking it down into the methyl and adenosylcobalamin forms (my mom and I both have constantly elevated methylmalonic acid and symptoms of B12 deficiency despite normal serum B12 levels)

Interestingly, we have reported that intranuclear localization of AIF involves in the peroxynitrite-induced apoptosis of SGNs (Liu et al., 2012), whether GPX1 regulates the intranuclear localization of mitochondrial AIF to alleviate apoptosis in SGNs after peroxynitrite injury deserved further exploration

The suppression of autophagy, which is induced by cisplatin, is due to its epigenetic suppression of FOXG1

1B), as defined in the methods