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This study revealed that higher ASC in ripening orange was associated with an augmented expression of four genes involved in ASC biosynthesis, encoding GDP-d-mannose-3,5-epimerase (EC 5.1.3.18), GDP-l-galactose-phosphorylase (EC 2.7.7.69), l-galactose dehydrogenase (EC 1.1.1.316) and l-galactono-1,4-lactone dehydrogenase (EC 1.3.2.3), together with attenuated activities of ASC oxidase and ASC peroxidase, which are involved in ASC degradation

Complementary Research Potential Because Cagrilintide and Retatrutide act through different biological pathways (amylin vs incretin/glucagon systems), they represent complementary tools for metabolic research

The following subsections outline key smart material strategies and functional outcomes, highlighting how hybrid nanomaterials through pH-responsive systems, peptide or polysaccharide conjugation, multifunctional hydrogels, antibiotic resistance modulation, and enzyme-based nanozymes translate these dual actions into clinically relevant wound-healing solutions

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