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Description

For prevention or in cases of mild deficiency, high-quality oral or sublingual preparations may suffice

Substitutions in the amyloidogenic core region were used to disrupt the beta-sheet propensity that drives fibril nucleation, allowing the analog to remain soluble and monomeric at formulation-relevant concentrations

Clinical guidance suggests at least 1.0 to 1.2 grams of protein per kilogram of body weight daily, with higher amounts for those who are physically active