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When to Be Concerned: Abnormal or Severe Reactions While most site reactions are benign, certain signs indicate a need for intervention : Warning Signs: Spreading redness or a halo that increases in size Severe pain that intensifies rather than resolves Hard, painful lump that doesnt go away after several days Pus , drainage, or signs of infection Blistering or skin breakdown Fever , chills, or flu-like symptoms Allergic reaction systemic itching, rash, or anaphylaxis (very rare) If you experience any of the above, stop using the peptide and contact your provider immediately