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Gastrointestinal conditions such as pernicious anemia (autoimmune destruction of gastric parietal cells), Crohn's disease, celiac disease, and prior gastric or ileal surgery significantly impair absorption

Holoceruloplasmin is functional and packed into vesicles, the content of which is released at the basolateral side to the circulation, representing the predominant Cu-binding protein in blood (95% of Cu found in plasma) (21-23)