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By providing both glycine and cysteine, GlyNAC ensures adequate glutathione production, which is crucial for protecting cells from oxidative damage and maintaining mitochondrial function

Conversely, excessive ROS oxidize and damage cellular components, leading to cellular death (Luo et al., 2020

Given that core metabolic processes, including nucleotide synthesis, glycolysis, and redox defense, are fundamentally shared with normal proliferative tissues, broad-spectrum metabolic inhibition often lacks true selectivity and precipitates dose-limiting systemic toxicities [43]

Additionally, tumor metastasis relies on the development of new blood vessels, a process known as angiogenesis, which selenium has been shown to suppress by modulating the expression of vascular endothelial growth factor (VEGF)