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In addition, aging leads to increased insulin resistance, which reduces MOTS-c levels in skeletal muscle and blood of mice (15)

Medications that reduce B12 absorption: Proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, and esomeprazole are amongst the most commonly prescribed drugs in elderly populations

Thyroid function tests (TSH, T3, T4) are particularly relevant for semaglutide patients, as thyroid conditions are both a common contributor to weight management difficulty and a consideration for treatment eligibility

Again, previous studies have focused on animal and cellular experiments, and due to the complex pathogenetic mechanisms involved in IVDD, the metrics used by scholars may be incomplete