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Lower bioavailability can be the result of poor or no absorption from the stomach and the intestines, so this step is an important one that can influence availability

The tripeptid glutathione, as the main antioxidant in the brain, is needed for the conversion of methylglyoxal, a toxic by-product of metabolism, into d-lactate by glyoxalase 1 (EC 4.4.1.5) [94,95]