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The significance of these findings for the immune-linked neurotoxicity/neuroprotective theory of MDD cannot be overlooked, as numerous proinflammatory cytokinessuch as IL-1, IL-6, IL-2, IL-8, IFN-, and IL-17along with various chemokines, including CCL2, CCL5, and IP10, have been demonstrated to exhibit neurotoxic effects

Fortified Immune System

Croissant JG, Fatieiev Y, Khashab NM

47 Although cardiomyocyte-specific increase of miR-222 was not sufficient to recapitulate the exercised heart phenotype, reducing miR-222 markedly attenuated exercise-induced physiological cardiac hypertrophy in vivo