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In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

IGF-binding protein 1 and abdominal obesity in the development of type 2 diabetes in women

Research protocols often begin with 0.25mg and may scale to 0.5mg or 1mg, depending on the experimental model and study goals

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