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In obese males without pathological hypogonadism, testosterone therapy, as an adjunct to lifestyle interventions, effectively prevents or reverses T2DM [356, 357]

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In rat hippocampal cultures, Nrn1 expression persists even when NMDA and AMPA receptors are blocked, indicating voltage-gated channels and calcium signaling can independently regulate Nrn1 , when glutamatergic transmission is pharmacologically blocked (Naeve et al., 1997)

While long-term research should be done to establish the clinical value of radioprotective agent use in the setting of medical imaging, the harm and cost of adding these agents is negligible