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Their function is likely similar to the hypothesized function of WAMs in mice, which is thought to include myelin debris clearance and lipid metabolism (Safaiyan et al., 2021)

Another tumor suppressor, retinoblastoma (Rb), can directly regulate the glutamine transporter ASCT2 ( SLC1A5 ) to reduce glutamine uptake via the transcription factor E2F3 (Reynolds et al., 2014)

The authors concluded that probiotic and prebiotic supplementation exerts measurable antioxidant and anti-inflammatory effects in this model, supporting their potential as complementary neuroprotective strategies ( Supplementation with three different lactobacillus strains to VPA-induced ASD mice improved behavioral symptoms compared to the risperidone group, a drug approved by the Food and Drug Administration