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Chronic alcohol use can also impair vitamin B12 absorption and utilization, potentially reducing the effectiveness of methylcobalamin supplementation

Bachmann J, Ketterer K, Marsch C, Fechtner K, Krakowski-Roosen H, Bchler MW, Friess H, Martignoni ME: Pancreatic cancer related cachexia: influence on metabolism and correlation to weight loss and pulmonary function

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In a previous study, UCH-L1, a DUB that removes Ub from Ub precursor proteins and hydrolyzes Ub carboxyl-terminal esters and amides (38), was found to be involved in regulating focal adhesions and adherens junctions, which is supported by co-immunoprecipitation with key components of these complexes, including FAK, paxillin, p120-catenin, -catenin, and vinculin (39)