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doi: 40

Cilostazol (Cls), a specific phosphodiesterase type-3 inhibitor, inhibits the degradation of cAMP, increasing its intracellular level, and subsequently activates protein kinase A

However, one must balance this with not eating too heavily or too late at night ( Dietary polyphenols and antioxidant-rich foods are primarily addressed as components of dietary patterns that support physiological resilience and redox balance during aging

Similarly, RNS, including nitric oxide (NO) and peroxynitrite (ONOO - ), contribute to nitrosative stress, exacerbating inflammatory signalling and impairing cellular function 11,12,13