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The enzyme hydroxyacid-oxoacid transhydrogenase (HOT) (B) oxidizes gamma-hydroxybutyric acid, a potentially toxic metabolite, to succinic semialdehyde, simultaneously reducing 2-ketoglutaric acid to D-2-OH glutaric acid

Moreover, vitamin E slows down the ROS production ( Cucinotta et al., evaluated a metabolic antioxidant therapy combining ubiquinol Q10, Vitamin E, and B-complex vitamins in 59 individuals (42 males and 17 females) with neurodevelopmental disorders

By activating soluble guanylate cyclase (sGC), NO elevates cyclic guanosine monophosphate (cGMP) levels, which relaxes smooth muscle and facilitates vasodilation (Wu et al., 2021)

Cetuximab-triptolide conjugate suppresses the growth of EGFR-overexpressing lung cancers through targeting RNA polymerase II