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12 Potential adverse effects and risk considerations of probiotic supplementation 12.1 Historical safety record and regulatory frameworks For centuries, the consumption of fermented foods containing live microorganisms has been associated with human health benefits, providing a strong historical foundation for their safety

Numerous human studies have shown that the cumulative load of high inflammation markers, such as IL-6, TNF-, ICAM-1, MCP-1, and C-reactive protein (CRP), is accompanied by increased risk for short TL or telomere dysfunction

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