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Patients returning to activities they had been avoiding due to pain or limited function

These strategies include nutraceuticals, probiotics/prebiotics and -3 supplementation, targeting glutamate transporters or selective 5-HT reuptake inhibitors, and intranasal OT treatment

Alternatively, daily high-dose oral supplements may be used that promote vitamin B12 absorption through passive diffusion along the length of the gastrointestinal tract ( Methylenetetrahydrofolate reductase deficiency As described above, the methyl group required for remethylation of homocysteine is provided by 5-methyltetrahydrofolate formed by MTHFR (Figure 2)

Bioavailability: Regarding B12, the most common form in dietary supplements is cyanocobalamin, a synthetic form of vitamin B12