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Among nonsteroidal anti-inflammatory drugs, aspirin dissociates mitochondrial-bound HK2 by disrupting its interaction with VDAC1, 1179 whereas diclofenac suppresses GLUT1 and HK2 activity, thus reducing glycolysis

Longer term For longer protocols, review IGF-1 and metabolic trends periodically with a clinician

Nakagawa T, Sanchez-Lozada LG, Andres-Hernando A, et al

ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]