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In fact, treatment of macrophages with itaconate, a well-known anti-bacterial product which is a by-product of citrate and TCA activity, induces the inhibition of aldolase during LPS stimulation and prevents the production of IL1 demonstrating that aldolase promotes the production of IL1 (93)

Treatment groups were (1) vehicle control, (2) GTN, (3) ascorbic acid (ASC), and (4) GTN + ASC

Together, these processes have mitochondrial iron metabolism underpinning both energy production and antioxidant capacity, thereby influencing cellular susceptibility to ferroptosis

- When you pop pimples, the bacteria spread into the skin, giving more pimples surrounding the area