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The intragastric administration route used in Sun 2021 reflects the BBB-permeability and oral-bioavailability profile characterized for Dihexa in the McCoy 2013 pharmacokinetic work

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Three strains of transgenic mouse were fed diets containing aspartame at a concentration of 0, 3125, 6250, 12 500, 25 000, or 50 000 ppm (equivalent to average daily doses of approximately 5008000 or 9000 mg/kg bw per day, depending on the strain and sex) for 9 months

359 In a mouse model of large-scale mtDNA deletion, Pearson syndrome-like anemia worsened with the knockout of Drp1, and Drp1 knockout alone also caused anemia