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The asynchronous variant rs2070600 (Gly82Ser), which is linked to both cancer risk and changes in circulating sRAGE, was used as a surrogate marker in a 2016 Mendelian randomized meta-analysis study [9] to infer a potential causal relationship, suggesting that lowered circulating sRAGE concentrations through genetic mechanisms may increase cancer risk

In addition to plants, H2O2 has been also demonstrated to act as a secondary messenger in mammalian cells, mediated through the activation of transcription activators, such as nuclear factor kB (NF-kB) (Schreck et al., 1991) and AP-1 (activator protein-1

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