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Description

FDA found no data supporting effectiveness through the nominated subcutaneous route

The removal of ligands is partially achievable by simply washing away all excess capping ligands, though this method is ineffective in removing all capping ligand

Moreover, all the AcM inclusion levels led to a decreased abundance of KOs encoding for the biosynthesis/metabolism of structural cell components, such as teichoic acid ( tagA , tagE , dltA , dltB , dltC , dltD , cpoA , mgs and bcrC ) and peptidoglycan ( murA , murB , murC , murD , murE , murF , murG , bcrC , dacC , ddl , mraY , pbp2A and pbpB ) of which murF , murG , mraY and ddl together with alr also led to a decrease in intrinsic vancomycin resistance