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Vitamin K, another fat-soluble vitamin, may be deficient in cirrhotic patients, but its supplementation remains highly controversial

Inflammation A critical feature that distinguishes hepatic steatosis from NASH is the presence of hepatic inflammation, particularly of resident Kupffer cells and recruited monocyte-derived macrophages ( Trem2 , Gpnmb , Cd9 , Spp1, and Itgax , genes associated with macrophages in NASH, accumulate in areas near desmin high hepatic stellate cells, revealing their capability to crosstalk with hepatic stellate cells to drive hepatic fibrosis ( Through a variety of mechanisms, macrophages in the liver exhibit a heightened state of inflammation and produce vast amounts of IL-1 ( 2.2.3

This review summarizes the various cellular events involved in AIH and discusses their potential therapeutic targets, with the aim of providing new ideas for the treatment of AIH