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Neuronal hyperexcitability can be a common link between CVS and other central nervous system (CNS) disorders.3840 Hyperexcitability can be a consequence of genetic variants in the structure and function of the ion channel and/or neurotransmitter receptors or can be the result of an aberrant development of neuronal circuits

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Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial oxidation of fatty acids to prevent lethal accumulation of longchain acylcarnitines in the mouse liver

pizotifen, amitriptyline, propranolol and cyproheptadine) had respectively 100%, 81%, 65% and 61% of response rate over 50% of reduction of number of episodes [3]