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* Correspondence: Huanbin Xu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In addition, chronic accumulation of fumarate by deletion of fumarate hydratase (FH) led to the formation of succinic GSH, a covalent adduct of fumarate and GSH, which correlated with persistent oxidative stress and cellular senescence in renal cells (121)