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A suboptimal intake of the essential amino acids increases the body's need for the non-essential amino acids either through diet or supplementation

Targeting ATFs in macrophages could be a potential therapeutic strategy Targeting ATFs in macrophages offers a promising therapeutic strategy, as these key transcription factors orchestrate diverse macrophage functional states, thereby enabling precise modulation of disease processes (Table III)

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Chemoproteomics and chemical probes for target discovery