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At the local level, the asthma-related changes include disturbances in the balance of Th1/Th2 pro- and anti-inflammatory cytokines, an increased cellular influx into the bronchi, chronic oxidative stress, and airway hyperreactivity

Epoetin alfa is a 165 amino acid glycoprotein manufactured by recombinant DNA technology, and has the same biological effects as endogenous erythropoietin Erythropoietin (Epo) stimulates red blood cell proliferation and differentiation by interacting with erythropoietin receptors on red cell progenitors

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