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SIRT3, a class III HDAC associated with longevity, deacetylates Forkhead box protein O3a (FOXO3a) and promotes transcription of antioxidant enzymes (e.g., manganese superoxide dismutase and catalase), thereby constraining mitochondrial ROS and preserving redox homeostasis [71, 72]

Activation of these pathways would increase intracellular ROS levels by inhibiting the transcription factor forkhead box transcription factor O (FOXO), which boost the production of antioxidants such as SOD2, catalase, and sestrin3 [28]

Particular focus should be placed on interactions between mHTT, the ironmetabolism axis (such as transferrin receptor 1 and hepcidin), and key ferroptosis mediators (GPX4 and Nrf2) to build a dynamic model linking mHTT aggregation, iron dysregulation, and neuronal ferroptosis, and to define subtype-specific vulnerability of MSNs

Introduction Spontaneous abortion (SA), also known as miscarriage, can occur before a pregnancy has been discovered and can involve several complications like an empty gestational sac, halted embryonic growth, embryo or fetus demise, and embryo expulsion and its associated tissues