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Exendin-4 (a peptide that shares 53% amino acid sequence with native GLP-1), however, was found to be effective in rat models for preventing 6-OHDA-induced DA-ergic neuron loss and increasing the number of neural stem cells in the subventricular zone ( 3.2.2.2 Clinical studies At the clinical level, RCTs have been carried out to evaluate the effects of some GLP-MA in PD patients (Table 2) ( p = 0.0068) primary outcome endpoint change in motor tests, and the positive effect persisted at 2 months after discontinuation of treatment ( p 3.0.co;2-5 J

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doi: 10.1002/mrc.5083 27 ShaoTJHeZXXieZJLiHCWangnMJWenCPet al

Cancer Cell 33 , 547562 (2018)