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GST fusion protein aggregates interfere with reproducible proteinprotein interactions and thus undermine the reliability of the GST pulldown experiment

Future research should concentrate on elucidating additional potential exhaustion-related biomarkers, developing novel drugs and therapeutic strategies capable of effectively reversing T-cell exhaustion, and simultaneously optimizing existing immunotherapy modalities such as combined application of epigenetic drugs, precise metabolic interventions, and engineered cell therapies

doi: 10.1016/j.biopha.2024.116615

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