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We chose P90 as the time of investigation, because this is a symptomatic stage with profound CSMN loss, and it coincides to the disease stage, when patients show symptoms and TDP-43 pathology begins to occur

To further explore the association of ASXL1 and BRD4 in the cellular context, we performed chromatin immunoprecipitation coupled with deep sequencing (ChIP-seq) of endogenous ASXL1, BRD4 and BAP1 and assessed genomic occupancies of these proteins in human HEK293T cells

10.1098/rsob.200309 62 FaneM.WeeraratnaA

For example, keeping your selenium levels within a tight range is associated with lower risk of heart disease because youre body is better able to handle and process stress