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Pineal peptide Epithalon prolongs life span in rats

EPIC-Norfolk: study design and characteristics of the cohort

Lingvay I, Sumithran P, Cohen RV, le Roux CW

The main mechanism is that miRNA-30b increases MMPs and autophagy in VSMCs by inhibiting mTOR signaling pathway, maintains mitochondrial homeostasis, and attenuates the phenotypic transformation of VSMCs to osteogenic phenotype