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Taking into account the main hypothesis of the autoimmune origin of MS, in which the disease would be triggered by the infiltration of autoreactive T lymphocytes in the CNS, it is reasonable to consider that lymphocyte secreted factors contribute to astrocytes activation in MS

Antibodies directed to Y chromosome antigens (H-Y antigens) in the setting of sex-mismatched HSCT have previously been implicated in both GVHD and GVL (199, 200)

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