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Guyer RD, Geisler FH, Holt RT, Majd ME, Regan JJ, , Wong DC, Jenis LG, Banco RJ, Blumenthal SL, DeMuth G, Hetzell BH: The Impact of Postoperative Disc Height following Arthroplasty on Long-term Clinical and Radiographic Outcomes a 5-Year Follow-up Study

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Toll-like receptor -four (TLR4) are innate immune activators which upregulate leucocyte infiltration into the myocardium and as a consequence, stimulates the secretion of cytokines, promotes oxidative stress, and releases proteases which in turn induce myocardial infarction or a heart attack, ischemic-reperfusion injury, myocarditis and heart failure

This effect was exhibited by upregulated transcriptional levels of antioxidant enzyme genes (SOD, CAT, POD, GPX), a decrease in MDA level, an increase in chlorophyll and proline contents, and modulation of photosystem II (PSII) activity