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Similarly, an original patient-derived glioblastoma cell line, KNS1451, obtained from Kyushu University Brain Tumor Bank, was cultured as previously reported 9

Uric acid (UA), traditionally associated with gout, is now gaining prominence as a potential target in neurodegenerative diseases

Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

Croteau et al., 2018a), suggesting normal mitochondrial functioning (Cunnane et al., 2016b, 2020), despite pronounced glucose hypometabolism