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Specifically, the VE of the bivalent original+BA.4/5 was estimated at 51.0%, and the VE of the original+BA.1 and monovalent ancestral vaccines was estimated at 49% and 27%, respectively

CD8 T cell hyperfunction was also observed in these mice, associating with increased mitochondrial respiration and glycolytic activity, and impaired responses to ectopic tumor growth and anti-PD-1 immunotherapy

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Specifically, CLP-induced systemic inflammation may activate microglia to secrete pro-inflammatory mediators, which suppress the Nrf2/HO-1/GPX4 redox axis, triggering mitochondrial dysfunction and oxidative stress