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Patient scores derived from the low vitamin B 6 map yielded strong correlations with patient phenotypes that were highly significant: Correlations in terms of Spearmans were 0.71 ( p = 0.05), 0.86 ( p = 0.003), and 0.93 ( p = 9.91 10 5 ) for age of onset, disease severity, and clinical vitamin B 6 response, respectively

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In diabetic children this state seems to be enhanced and facilitated so that accelerated atherosclerosis is associated with an increased risk of cardio-vascular events compared to the non-diabetic population