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Additionally, the presence of publication bias suggested by Eggers test and funnel plot asymmetry indicates that smaller studies with non-significant results might be underrepresented

By promoting a balanced stress response, probiotics may assist in regulating adrenal hormone production and mitigating the harmful effects of stress-induced oxidative stress (188)

This divergence between traditional and modern formulations introduces substantial heterogeneity in pharmacological exposure, complicating direct extrapolation between preclinical models and real-world human use

National Center for Advancing Translational Sciences / NIH