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doi: 10.1159/000012183 20 BaderDAMcGuireSE

Inhibitors of transporter proteins Many studies have reported that cisplatin can enter cochlear hair cells via various cation transport proteins and MET machinery formed by transmembrane channel-like 1 and 2 (TMC1/2), LHFPL tetraspan subfamily member 5 protein (LHFPL5), transmembrane inner ear protein (TMIE), calcium and integrin-binding family member 2 (CIB2), and tip link proteins (Protocadherin-15 and Cadherin-23) ( A report suggests that the inhibition of MET by quinine or ethylene glycol tetraacetic acid (EGTA) can prevent cisplatin-induced hair cell death (Thomas et al., 2013)

Clinicians often look at folate levels when considering the psychological wellbeing of patients, especially since these levels can impact the efficacy of antidepressants

HP1 Heterochromatin protein 1 (HP1), encoded by the Cbx1 gene, is actively involved in processes like chromatin condensation, transcriptional regulation, and DNA damage repair [105]