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Simona Cavalu, [email protected] ORCID: Abdullah Al Mamun, orcid.org/0000-0001-9936-3925 This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, it is becoming increasingly evident that autophagosomes can selectively engulf substrates including aggregate-prone proteins (aggrephagy) 61 , dysfunctional mitochondria (mitophagy) 62 and the endoplasmic reticulum (ER-phagy) 63